https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21292 in vitro. The impact of the anti-angiogenic properties on airways hyperresponsiveness (AHR) was then examined using a murine model of chronic OVA-induced allergic airways disease. Results: The LF-15 and T7 peptides significantly reduced endothelial cell viability and attenuated tube formation in vitro. Mice exposed to OVA+ LF-15 or OVA+T7 also had reduced total lung vascularity and AHR was attenuated compared to mice exposed to OVA alone. T3 peptides reduced cell viability but had no effect on any other parameters. Conclusion: The LF-15 and T7 peptides may be appropriate candidates for use as novel pharmacotherapies due to their small size and anti-angiogenic properties observed in vitro and in vivo.]]> Wed 11 Apr 2018 11:14:04 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15122 Tue 13 Aug 2024 10:06:20 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:39194 Thu 26 May 2022 15:47:31 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17952 Sat 24 Mar 2018 07:56:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4735 Sat 24 Mar 2018 07:21:10 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:24495 2+ and ROS waves), chemical (assimilates, hormones, peptides and nutrients), and molecular (proteins and RNA) signals. Further, different signalling systems operate at very different timescales. It remains unclear whether some of these signalling systems operate in a priming mode(s), whereas others deliver more specific information about the nature of the signal, or whether they carry the same 'weight'. This review summarises the current knowledge of the above signalling mechanisms, and reveals their hierarchy, and highlights the importance of integration of these signalling components, to enable optimal plant functioning in a dynamic environment.]]> Sat 24 Mar 2018 07:13:15 AEDT ]]>